listening to https://youtu.be/xJsl_klqVh0
He says (~3:20):
-- But we know the big stuff is made of the small stuff ... so there must be a way to understand the whole thing with one fundamental theory.
Nope.
At each scale different laws apply. There is no reason to assume that since the big stuff is made up of the small stuff the laws are the same for both.
For example, political law should change as a function of scale, communist with my family, socialist with my neighborhood and capitalist with my nation.
The distance between amino acids does not provide a measure of the functionality of proteins.